MRKH Syndrome: Newest Treatment! – Antai Hospital

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. It affects at least 1 out of 4500 women. MRKH may be isolated (type I) but it is more frequently associated with renal, vertebral, and, to a lesser extent, auditory and cardiac defects (MRKH type II or MURCS association). The first sign of MRKH syndrome is a primary amenorrhea in young women presenting otherwise with normal development of secondary sexual characteristics and normal external genitalia, with normal and functional ovaries, and karyotype 46, XX without visible chromosomal anomaly. The phenotypic manifestations of MRKH syndrome overlap with various other syndromes or associations and thus require accurate delineation. For a long time the syndrome has been considered as a sporadic anomaly, but increasing number of familial cases now support the hypothesis of a genetic cause. In familial cases, the syndrome appears to be transmitted as an autosomal dominant trait with incomplete penetrance and variable expressivity. This suggests the involvement of either mutations in a major developmental gene or a limited chromosomal imbalance. However, the etiology of MRKH syndrome still remains unclear. Treatment of vaginal aplasia, which consists in creation of a neovagina, can be offered to allow sexual intercourse.

The latest treatment method for MRKH Syndrome at Antai Hospital is to reconstruct the uterus and vagina by using displaced uterine and vaginal tissue. Patients are urge to sign a contract with us to ensure that there is indeed a presence of a uterus and vagina post-operation, and will require no use of any vaginal mold thereafter. For achieving pregnancy, eggs can be retrieved and collected from the ovaries for surrogacy.

MRKH patients often have what we call “double absence”, which means the have congenital absence of both the uterus and vagina. However, these tissues are simply displaced or “lost”, situated in wrong places, causing this absence. The tissues that are required to build these missing organs are already present, simply “misplaced”. For example, it’s just like when you don’t have a shirt but you have all the cloth and materials you need to make a shirt. All you need is a tailor.

At Antai Hospital, our doctors are your tailors. Under the endoscope and microscope, our doctors can locate these “lost” tissues, and use them for the reconstruction surgery of the uterus and vagina. This treatment comes with a full refund guarantee to give our MRKH patients peace of mind. If you cannot detect any presence of your new uterus and vagina post-surgery, or if you still need dependence on vaginal molds, then we must refund the full treatment cost to you.

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