Immunological factors and recurrent early miscarriage
Introduction
According to the patents published by Antai Hospital experts: US7674590B2; What most reproductive experts and doctors identify as “unexplained miscarriages” are mostly caused by immunological factors, also known as an immunological miscarriage. It remains unexplained by most experts due to a lack of research or specialisation in this area.
Furthermore, there also exists several misdiagnosis and ineffective treatment today such as HLA testing, Anti-phospholipid Antibody testing, Lymphocyte immunotherapy etc. for these immune-miscarriages patients. Not only are they ineffective in treating their miscarriages, but they also end up wasting the precious time and money of these patients.
Antai Hospital has the internationally patented rights and recognition in the treatment and diagnosis of immunological miscarriages, having thoroughly determined the root cause of these so call “unexplained miscarriages”. Our excellent track record speaks for itself with over 300-400 patients yearly with a 95% success rate.
Diagnosis
To diagnose immunological recurrent miscarriage, a sample of your blood will be acquired for blood test and screening will be done via ELISA.
- If the levels of antinuclear antibodies in your blood is higher than 1:64, it is considered a positive result.
- If the levels of antinuclear antibodies in your blood is lower than 1:64, it is considered a negative result.
The results of the blood test only serve as supplementary information, the final diagnosis still lies on the doctor. He/She will make an informed and accurate decision based on not only the blood test results, but also your symptoms and medical history.
Treatment
Antai Hospital’s immunotherapy works by inoculating a gene vaccine from the husband’s blood that can effectively counteract the anti-embryonic antibodies. The mechanism of action is by injecting filtered paternal cells carrying the identical chromosome 2 antigen, we can effectively negate the activity of the anti-embryonic antibodies, a form of immunity known as “immune-escape”. Although our immunotherapy does not eliminate the antibodies, it prevents the possibility of an immunological miscarriage and allows for a successful and healthy pregnancy to develop.
Step 1: Before treatment, the patient will be tested for presence of anti-embryonic antibodies, for
her hormonal levels, hysteroscopy test etc.
Step 2: Our doctors will acquire 160ml of venous blood from the patient’s husband, which will be
used to make the gene vaccine.
Step 3: The blood acquired will then be separated to its base components via centrifuge to isolate
the nuclear cells in the husband’s blood.
Step 4: The acquired sample will be proliferated and processed in the laboratory using PCR. Cell
division will cause the chromosomes in the nuclear cell to replicate.
Step 5: We will now isolate the specific gene (chromosome 2) that is responsible for the encoding of
the fibronectin protein and inoculate it into a “vaccine”. This process takes about 4 days.
Step 6: Patients will now be administered with the gene vaccine via intramuscular injection.
The entire course of treatment has 2 effective periods:
- 4 injections per week before getting pregnant.
- 4 injections per week after getting pregnant
*Please note that the patient must try for pregnancy as soon as the first 4 injections are administered within a 6-month period, the sooner the better.
The first vaccination will be done in the hospital, while the remaining 7 can be done at the comfort of your home. The vaccines are easy to administer and can be brought home.
Antai Hospital will provide a vaccine carrier box with the frozen vaccines for you to bring home. While at home, the vaccines can be kept in freezing conditions in the refrigerator and has a shelf life of up to 2 years.
Special cases
- In case you are already pregnant and tested positive for the presence of anti-embryonic antibodies, you must undergo the immunotherapy as soon as possible to avoid a possible immunological miscarriage. Please discuss with our doctors upon consultation.
- If the husband is not present, no longer around or has a possible infection that renders his blood dangerous to use, Antai Hospital will opt for the use of cord blood, which is safe and effective in counter-acting the effects of anti-embryonic antibodies. Additional fees may apply.
How does immunological factor cause an early miscarriage?
Immunological factors cause an early miscarriage due to the formation and presence of a special type of antibodies, known as Anti-Embryonic Antibodies. Anti-Embryonic antibodies, as its namesake, targets embryonic cells, specifically these ANAs (anti-nuclear antibodies) target the chromosome 2 of the embryo during its rapid development in the early stages of pregnancy. It seeps pass the cell membrane of the embryonic cells and binds with the chromosome 2 as it is rapidly dividing during cell division, causing it to cease the production of the fibronectin layer.
This fibronectin layer that lines the microvilli of the embryonic cells serves as an immunological barrier between the maternal and embryonic cells. Without it, the embryo will be eliminated by the mother’s immune cells as they register the embryo as a foreign protein, causing what we define as an “immunological miscarriage”
How does a woman develop an immunological factor?
Immunological factors arise due to the presence these anti-embryonic antibodies in the mother’s body during a pregnancy. During an induced abortion procedure, when demised fetus or embryo (and its attachments) is being removed from the mother’s uterus, there is a high risk of damaging the uterus lining via scraping. This exposes the uterine veins and allows these fetal cells carrying paternal genes to enter into the mother’s bloodstream.
Once registered by the maternal immune system as an invading pathogen, her body develops these anti-embryonic antibodies as an immune response to attack and eliminate the fetal cells. In subsequent pregnancies, unbeknownst to the mother and undetected in prenatal check-ups, these antibodies already present in the mother’s body start carrying out their function once more, causing an immunological miscarriage. If left untreated, it will complicate into “recurrent immunological miscarriage” in all your subsequent pregnancies/
If you have undergone the following you may risk developing anti-embryonic antibodies:
- Induced Abortions (67%)
- Childbirth
- Sexual intercourse during menses
All of the above allows the possibility of paternal genes to enter into the maternal bloodstream, leading to the formation of these anti-embryonic antibodies.
Our Patents
- Methods for Diagnosing and For Monitoring the Treatment of Recurrent Spontaneous Abortion; US7674590B2; United States Patent.
- A Pharmaceutical Composition Used for Treating Recurrent Spontaneous Abortion and Method Thereof; EP1719516B1; European Patent.
If you would like a consultation or an appointment with us, please contact us today.
Antai Hospital’s Commitment
Antai Hospital’s full refund policy for the miscarriage prevention treatments we provide should already be the best guarantee for a healthy pregnancy. Patients should rest assured, can and should go about their everyday life, focusing their diet on vegetables, beans, celery, and other fiber-rich foods. Besides that, an active lifestyle of yoga and swimming should also be incorporated to help relieve stress and increase blood circulation, which is beneficial for the fetus’s development and the mother’s health. With our assurance, a healthy lifestyle, and peace of mind, you can go through a healthy pregnancy with no complications.
Recurrent miscarriages are no doubt a heavy blow to the patient’s physical and mental health. All we can do is to help ease the burden and decrease your trauma, to slowly help you overcome the anxiety with the love and care that we provide at Antai Hospital.
Trust in Antai Hospital and trust in yourself, your pregnancy is our priority.