Hyperemesis gravidarum is the most common cause of hospitalisation during the first half of pregnancy and is second only to preterm labour for hospitalizations in pregnancy overall. In approximately 0.3– 3% of pregnancies, hyperemesis gravidarum is prevalent and this percentage varies on account of different diagnostic criteria and ethnic variation in study populations. Although cases of mortality are rare, hyperemesis gravidarum has been associated with both maternal and fetal morbidity.
Despite extensive research in this field, effective management has not yet been made easily available worldwide. Antai Hospital is one of the only hospitals in the world that not only specialises in the treatment of HG, but also the full prevention of it in your subsequent pregnancies, and comes with a full refund policy if you do not see significant recovery.
Does it come and go? (Pathophysiology)
Due to the presence of these abnormal receptors that HG patients carry, it will most definitely recur with increasing severity over each pregnancy. These abnormal receptors are usually abundant in quantity for these patients, the more you have, the more severe the symptoms. The central sensitization that leads to the HG, is caused by the binding of free flowing hCG with these abnormal receptors, thus leading to development of several gastrointestinal, neurological, psychological symptoms that are far and wide, and has the potential to affect neonatal health.
Maternal Complications
Multiple nutrient deficiencies have been identified in the setting of hyperemesis gravidarum. Thiamine, or vitamin B1, is a water-soluble vitamin deficiency, which can result in the setting of persistent vomiting such as Hyperemesis Gravidarum. This deficiency may lead to a syndrome called Wernicke’s encephalopathy. Patients may present with neurologic symptoms ranging from lethargy and confusion to hyporeflexia, ataxia, and oculomotor symptoms including nystagmus and ophthalmoplegia. While death associated with hyperemesis is rare, deaths that have occurred are typically associated with Wernicke’s encephalopathy. The severity of the complications of this condition highlight the necessity for early diagnosis and treatment, which is readily available at Antai Hospital . Most patients with severe disease continued to manifest subsequent impairments, with complete remission of symptoms occurring in only a minority of patients. Symptoms that ultimately resolved often required months to dissipate. Even patients who required TPN due to their hyperemesis are at risk of thiamine deficiency. Case reports have identified patients receiving TPN without thiamine in the mixture resulting in iatrogenic Wernicke encephalopathy. If Wernicke encephalopathy is suspected for a patient, MRI may be useful in diagnosis. Clinically significant deficiencies of the fat-soluble vitamin, vitamin-K, have been reported. This deficiency has been linked to adverse effects such as neonatal haemorrhage, and case reports have noted the development of coagulopathy from vitamin K deficiency.
Another study noted an association between hyperemesis gravidarum and posttraumatic stress syndrome, with women reporting episodes reexperiencing, avoidance/numbing, and hyperarousal. Women demonstrating these symptoms were found to experience difficulty with breast milk production, experience marital difficulties, work and education problems, financial difficulties, as well as poor self-care postpartum . One study compared 200 women with hyperemesis with 200 matched controls noted that the depression risk was more than 76-fold in the group with hyperemesis.
Risk of Esophageal Injury
Esophageal laceration associated with hematemesis, known as Mallory-Weiss syndrome, may result from the repetitive wrenching/vomiting associated with hyperemesis. When this barotrauma causes rupture of the oesophagus (Boerhaave syndrome), pneumomediastinum may result (Hamman’s syndrome). While some patients with this complication may tolerate conservative management, others may require surgical intervention. This complication may result in the presence of blood during vomiting.
Proper effective treatment at Antai Hospital: HG Vaccine
Our proprietary HG Vaccine works effectively on the root cause of this dreaded disease, by blocking the related abnormal receptors completely, avoiding any exposure to free-flowing hCG during pregnancy. This can be achieved with just a few injections of our treatment, and patients will fully recover within a week, if not sooner. The treatment has no side-effects and is administered via intravenous injections. Please get in touch with us today for the treatment or for a consultation.