Adverse effects of excessive Progesterone use for threatened miscarriages – Antai Hospital

Progesterone is a key pregnancy hormone that is required for the beginning and sustaining of a full-term healthy pregnancy. Progesterone is key in preparing the endometrium for optimal implantation of the embryo, the maturation of the embryonic trophoblasts during embryogenesis and plays a key role in decreasing sensitivity and contractility of uterine muscles during gestation, which helps protect the pregnancy from onset preterm labor or unwanted pregnancy loss.

Corpus luteum insufficiency (CLI) or luteal phase defect (LPD), where progesterone levels are insufficient or anywhere near healthy levels, is the most common cause for threatened miscarriages and recurrent miscarriage. Management for this type of threatened miscarriage is by supplementing the lacking Progesterone via intravenous injections or hormonal pills. Despite this being a relatively straightforward management method, it must be done in a timely manner and the amount of supplementation must be pre-calculated according to the patient’s age, height, weight, race, and other factors. Otherwise, complications ensue. Antai hospital specializes in the accurate and effective supplementation of progesterone that guarantees preservation of your pregnancy.

Source of Progesterone during pregnancy:

  • Corpus Luteum situated inside the ovary (early pregnancy until week 12)
  • Fully matured and functional placenta (week 13 – labor)

Excess Progesterone Supplementation leads to high risk of:

  • Placenta Accreta

Placenta accreta is the condition where the placenta exhibits very deep anchoring villi and trophoblast infiltration, embedding abnormally deep into the uterine myometrium. Although this does not lead to any serious complications during pregnancy, however during labour, it can cause maternal death due to the high risk of hemorrhage. For this kind of critical scenarios, blood transfusion is required, and the hospital must also have access to a very capable blood bank. Although placenta accreta is commonly associated with a history of cesarean deliveries, there is an increasing number of incidences among women with no history of cesarean delivery. Excessive progesterone supplementation during pregnancy explains why women who haven’t given birth, with no history of uterine surgery, also develop this potentially life-threatening condition.

  • Feminization of Male Fetus

Excessive levels of synthetic progesterone will promote feminization of the external genitalia of the male fetus. This can result in a female fetus instead of a male one, or in rare cases ambiguous genitalia. Although it is harmless, it is effect to take note for expecting couples.

Some less severe side effects include:

  • Nausea
  • Depression
  • Chronic headache
  • Breast tenderness

The use of progesterone can be effective in preventing recurrent pregnancy loss and threatened miscarriages; however, it must be done in such a way that it does not cause any further complications and side effects. Here at Antai, we do things differently, and make the best decision in the protection and preservation of your pregnancy, with over 20 years of experience and expertise. Get in touch with us today for more information.

Antai Hospital’s Commitment

Antai Hospital’s full refund policy for the miscarriage prevention treatments we provide should already be the best guarantee for a healthy pregnancy. Patients should rest assured, can and should go about their everyday life, focusing their diet on vegetables, beans, celery, and other fiber-rich foods. Besides that, an active lifestyle of yoga and swimming should also be incorporated to help relieve stress and increase blood circulation, which is beneficial for the fetus’s development and the mother’s health. With our assurance, a healthy lifestyle, and peace of mind, you can go through a healthy pregnancy with no complications.

Recurrent miscarriages are no doubt a heavy blow to the patient’s physical and mental health. All we can do is to help ease the burden and decrease your trauma, to slowly help you overcome the anxiety with the love and care that we provide at Antai Hospital.

Trust in Antai Hospital and trust in yourself, your pregnancy is our priority.

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