Hyperemesis Gravidarum Causes Violent Vomiting – Antai Hospital

Hyperemesis Gravidarum: The constant, violent vomiting

Hyperemesis Gravidarum is one of the rarest pregnancy disorders that is equally devastating in terms of severity, and how it affects the mother’s health during pregnancy. The 4 predominant symptoms include:

• Violent, persistent vomiting (bile & blood)
• Hypersalivation
• Insomnia
• Constant Nausea

The symptoms escalate to very severe levels, affecting the mother’s ability to sleep, eat and drink, causing dehydration and starvation, leading to rapid weight loss during gestation and malnourishment for the pregnancy. According to ur experience here at Antai Hospital, Hyperemesis Gravidarum is considered a prominent cause for pregnnacy loss and recurrent miscarriage, and has been a cause of maternal death in the past.

How does vomiting occur during Hyperemesis Gravidarum?

Hyperemesis Gravidarum is caused by the binding of hCG hormones secreted during gestation, with abnormal receptors (only HG patients carry these receptors). These receptors detect hCG and instantly generates a binding reaction, which induces the vomiting reaction.

These receptors are abundantly present in the CTZ, the chemoreceptor trigger zone located in the vomiting centre of the brain, inside the medulla oblongata.The chemoreceptor trigger zone is a circumventricular organ (CVO), in that it serves as a link between the brain parenchyma and the cerebrospinal fluid (CSF) containing ventricles. Its composition is of glia and neurons, covered by a thin ependymal cover, and penetrated with convoluted capillaries lacking tight endothelial junctions. This specialised structure means the CTZ within the AP forms a permeable blood-brain barrier and can detect emetic toxins in both the blood and the CSF.

Blood flow velocity in the capillaries of the chemoreceptor trigger zone is slow, extending the length of time blood, circulating messengers, and toxins are moving through this zone, allowing increased contact time for blood and its contents to penetrate the permeable capillaries and interact with receptors for various substances involved in homeostasis and body fluids. CTZ that relay information to the vomiting centre to induce emesis include the GI tract, the vestibular system, and the higher centres in the cortex and thalamus. This is how hCG easily encounters these abnormal receptors, and once the binding process is achieved, the patient begins exhibiting the disease with over 20 clinical symptoms.

The vomiting gets so severe that it causes esophageal tearing, bloody vomit (bile) and gastric erosion. This rapidly leads to ketoacidosis and causes a vicious cycle very quickly, and rarely does conventional treatment such as Ondansetron, Zofran ever work in curbing the condition.

Treatment for Hyperemesis Gravidarum: Antai’s HG Vaccine

Antai Hospital offers our proprietary HG vaccine that can effectively block the binding reaction from taking place, and the result is full recovery from Hyperemesis Gravidarum. This treatment comes with a full refund guarantee, if you do not see effective recovery or if you still cannot secure that pregnancy, treatment cost will be fully refunded. Over 10,000 patients have received this treatment, and all have gone on to recover and give birth to healthy babies.

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